Mounjaro and Unwanted Aesthetic Effects

In recent months, Dr. Renata Melo has noticed a significant increase in the number of patients coming to her office with complaints of pronounced facial sagging — popularly known as 'melting face' — and significant hair loss. Most of these women have in common the use of Mounjaro, a tirzepatide-based medication approved for the treatment of type 2 diabetes, which is also used off-label for weight control.

According to endocrinologist Gisele Lorenzoni, recent research has shown that Mounjaro can significantly reduce circulating blood sugar levels, as well as have a considerable impact on weight loss.” According to her, the substance is capable of delaying stomach emptying and prolonging the feeling of fullness. "In addition, it inhibits brain signals of hunger. As a result, appetite decreases,” explains the doctor. Dr. Renata Melo reports that Mounjaro has become popular for promoting rapid weight loss, but not everyone is prepared for the side effects that may arise. According to her, the abrupt loss of body fat can compromise skin support, especially in the facial area, resulting in sagging, more pronounced grooves, and a premature aging appearance.

“With weight loss, skin sagging is common. In addition, the appearance of deeper dark circles, a defined jawline… It’s as if they have lost the volume that provided support and youthfulness to the face,” she states.

Another effect observed by the doctor is hair loss, which may be related to a deficiency of essential nutrients during the process. “The body prioritizes vital functions and ends up not adequately nourishing the hair. Metabolic stress also contributes,” she explains.

To address these complaints, Dr. Renata has been investing in modern and effective resources, such as cutting-edge technologies, including Ultraformer MPT and the award-winning Oligio X, as well as collagen biostimulators, which stimulate the natural production of the substance and help restore skin firmness. The protocol also includes botulinum toxin, indicated to soften wrinkles and prevent new expression lines. “Each treatment is individualized and considers the degree of sagging, age, lifestyle, and the expectations of each patient,” the doctor emphasizes.

According to her, it is essential that anyone using Mounjaro has multidisciplinary medical supervision, including a nutritionist and an endocrinologist. “Weight loss can be an ally of self-esteem, but it needs to be accompanied by care for skin and hair health.